EC Number |
Reaction |
Reference |
---|
2.5.1.108 | S-adenosyl-L-methionine + L-histidine-[translation elongation factor 2] = S-methyl-5'-thioadenosine + 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine-[translation elongation factor 2] |
- |
- |
2.5.1.108 | S-adenosyl-L-methionine + L-histidine-[translation elongation factor 2] = S-methyl-5'-thioadenosine + 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine-[translation elongation factor 2] |
The relevant histidine of translation elongation factor 2 is His715 in mammals, His699 in yeast and His600 in Pyrococcus horikoshii |
718109 |
2.5.1.108 | S-adenosyl-L-methionine + L-histidine-[translation elongation factor 2] = S-methyl-5'-thioadenosine + 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine-[translation elongation factor 2] |
unlike the enzymes in the radical S-adenosyl-L-methionine superfamily, Dph2 does not form the canonical 5'-deoxyadenosyl radical. Instead, it breaks the Cgamma,Met-S bond of S-adenosyl-L-methionine and generates a 3-amino-3-carboxylpropyl radical |
723263 |