EC Number   |
Reaction |
Reference |
|---|
    2.4.1.186 | UDP-alpha-D-glucose + glycogenin = UDP + alpha-D-glucosylglycogenin |
conformational plasticity of glycogenin and coexistence of two modes of glucosylation as integral to its catalytic mechanism, possible SNi-like mechanism for glucosyl-transfer, overview |
723645 |
| 2.4.1.186 | UDP-alpha-D-glucose + glycogenin = UDP + alpha-D-glucosylglycogenin |
highly conserved protein |
637622, 638246, 638249 |
| 2.4.1.186 | UDP-alpha-D-glucose + glycogenin = UDP + alpha-D-glucosylglycogenin |
independent active sites for glucosylation of exogenous and self-acceptors |
638246 |
| 2.4.1.186 | UDP-alpha-D-glucose + glycogenin = UDP + alpha-D-glucosylglycogenin |
initiation of glycogen biosynthesis is a 2-step mechanism, requiring first the covalent attachment of a glucose residue to Tyr-194 of glycogenin and then elongation to form an oligosaccharide chain |
638249 |
| 2.4.1.186 | UDP-alpha-D-glucose + glycogenin = UDP + alpha-D-glucosylglycogenin |
stereochemistry and mechanism |
637622 |
| 2.4.1.186 | UDP-alpha-D-glucose + glycogenin = UDP + alpha-D-glucosylglycogenin |
The glycogenin subunit of glycogen synthase (EC 2.4.1.11, glycogen(starch) synthase) catalyses this reaction, i.e. the enzyme catalyses its own autoglycosylation. Five molecules of glucose can be transferred to one molecule of glycogenin. The product acts as a primer for the reaction catalysed by glycogen synthase. |
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