EC Number |
Reaction |
Reference |
---|
2.3.1.37 | succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2 |
5-aminolevulinate synthase operates under the stereoelectronic control predicted by Dunathans hypothesis |
687586 |
2.3.1.37 | succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2 |
covalent binding of pyridoxal 5'-phosphate and glycine to active site Lys131 is required for optimal activity |
486849 |
2.3.1.37 | succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2 |
cysteine in heme-regulatory motif |
486850 |
2.3.1.37 | succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2 |
Lys313 acts as a general base during formation of the quinonoid reaction intermediates |
486859 |
2.3.1.37 | succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2 |
mechanism |
-, 486813, 486819, 486820, 486821, 486826, 486845, 486850, 486859 |
2.3.1.37 | succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2 |
mechanism, aldimine linkage between pyridoxal 5-phosphate and enzyme |
-, 661787 |
2.3.1.37 | succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2 |
ordered bi-bi mechanism in which glycine binds first and 5-aminolevulinic acid dissociates last |
-, 486845, 486850 |
2.3.1.37 | succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2 |
proposed chemical mechanism of enzyme ALAS2 via (I) internal aldimine complex, (II) glycine-external aldimine, (III) quinonoid intermediate I, (IV) glycine-succinyl-CoA condensation intermediate, (V) 2-amino-3-ketoadipate intermediate, (VI) enol intermediate, (VII) quinonoid intermediate II, and (VIII) 5-aminolevulinate-external aldimine |
736491 |
2.3.1.37 | succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2 |
proposed chemical mechanism of enzyme ALAS2. via (I) internal aldimine complex, (II) glycine-external aldimine, (III) quinonoid intermediate I, (IV) glycinesuccinyl-CoA condensation intermediate, (V) 2-amino-3-ketoadipate intermediate, (VI) enol intermediate, (VII) quinonoid intermediate II, and (VIII) 5-aminolevulinate-external aldimine |
736116 |
2.3.1.37 | succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2 |
pyridoxal 5'-phosphate binding site, sequence and function of glycine-rich motif |
486850, 486851 |