EC Number   |
Reaction |
Reference |
|---|
   1.5.1.7 | N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O = L-lysine + 2-oxoglutarate + NADH + H+ |
mechanism |
396555, 396556, 396563, 396568 |
| 1.5.1.7 | N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O = L-lysine + 2-oxoglutarate + NADH + H+ |
model of proton shuttle mechanism. Concerted proton and hydride transfer, proton transfer exists in at least two sequential transition states |
672274 |
| 1.5.1.7 | N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O = L-lysine + 2-oxoglutarate + NADH + H+ |
ordered addition of NAD followed by saccharopine in the physiologic reaction direction. In the opposite direction, NADH adds to the enzyme first, while there is no preference for the order of binding of alpha-ketoglutarate and lysine |
672073 |
