EC Number |
Reaction |
Reference |
---|
1.5.1.20 | 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+ |
- |
- |
1.5.1.20 | 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+ |
mechanism |
392153, 392155 |
1.5.1.20 | 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+ |
mechanism, acceptor is free FAD, stereochemistry |
437711 |
1.5.1.20 | 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+ |
MTHFR is proposed to use the mechanism of flavin-based electron bifurcation |
-, 764937 |
1.5.1.20 | 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+ |
NADH adopts a hairpin conformation and is sandwiched between a conserved phenylalanine, F223, and the isoalloxazine ring of FAD, resulting in a complex competent for hydride transfer. The binding sites of the two substrates overlap. Pinog-pong reaction is facilitated by motions of loops L2, L3, L4 |
671972 |
1.5.1.20 | 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+ |
ping-pong bi-bi mechanism, in which NAD(P)+ release precedes the binding of methylenetetrahydrofolate |
437726 |
1.5.1.20 | 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+ |
substrate binding and catalyic mechanism involve Asp120, half-reaction mechanisms |
654771 |