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Results 1 - 2 of 2
EC Number Reaction Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 1.5.1.155,10-methylenetetrahydrofolate + NAD+ = 5,10-methenyltetrahydrofolate + NADH + H+ - -
Display the word mapDisplay the reaction diagram Show all sequences 1.5.1.155,10-methylenetetrahydrofolate + NAD+ = 5,10-methenyltetrahydrofolate + NADH + H+ the reaction catalyzed by Escherichia coli MTHFR can be divided into a reductive half-reaction and an oxidative half-reaction, respectively, in which the FAD cofactor acts as an intermediate electron acceptor and donor. The enzyme employs a ping-pong bi-bi kinetic mechanism, in which the release of NAD+, the product of the first half-reaction, precedes binding of the substrate CH2-H4folate in the second half-reaction. Rapid-reaction kinetic studies have established that the enzyme catalyzes these half-reactions at rates consistent with the observed rate of overall turnover. Proposed mechanism for the oxidative half-reaction, overview 760434
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