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EC Number Reaction Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.67D-mannitol + NAD+ = D-fructose + NADH + H+ - -
Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.67D-mannitol + NAD+ = D-fructose + NADH + H+ binding of substrate and NAD(H) is random for both D-mannitol oxidation and D-fructose reduction. Hydride transfer is rate-determining for D-fructose reduction. Product release steps control the maximum rates in the other direction of the enzymatic reaction 722234
Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.67D-mannitol + NAD+ = D-fructose + NADH + H+ the oxyanion hole of mannitol 2-dehydrogenase drives a precatalytic conformational equilibrium at the ternary complex level in which the reactive group of the substrate is activated for chemical conversion through its precise alignment with the unprotonated side chain of Lys295 in mannitol oxidation and C=O bond polarization by the carboxamide moieties of Asn191 and Asn300 in fructose reduction. In the subsequent hydride transfer step, the two asparagine residues provide about 40 kJ/mol of electrostatic stabilization 711136
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