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Results 1 - 8 of 8
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EC Number Reaction Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.6217beta-estradiol + NAD(P)+ = estrone + NAD(P)H + H+ 17beta-HSD2 and 5 catalyzes the reaction of estradiol-17beta to estrone and testosterone to androstenedione, 17beta-HSD2 also has 20alpha-HSD activity 656645
Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.6217beta-estradiol + NAD(P)+ = estrone + NAD(P)H + H+ 5 isoforms with different substrate specificities and tissue distribution, 17beta-HSD1 predominantly catalyzes the reaction of estrone to estradiol-17beta, 17beta-HSD2 catalyzes the reaction of estradiol-17beta to estrone and testosterone to androstenedione, 17beta-HSD3 and 5 catalyzes the reaction of androstenedione to testosterone, 17beta-HSD4 catalyzes the reaction of estradiol-17beta to estrone with low substrate affinty 656644
Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.6217beta-estradiol + NAD(P)+ = estrone + NAD(P)H + H+ a structural analysis of available crystal structures is performed and representative conformations are assigned to each step of the putative kinetic mechanism. An essential role played by the backbone and side chain motions, especially of the betaFalphaG’-loop, in cofactor and substrate binding is disclosed. A selected-fit mechanism is suggested for 17beta-HSD1, where ligand-binding induces concerted motions of the FG-segment and the C-terminal part guide the enzyme along its preferred catalytic pathway 713367
Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.6217beta-estradiol + NAD(P)+ = estrone + NAD(P)H + H+ active site structure of isozymes 17beta-HSD1 and 17beta-HSD14 675983
Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.6217beta-estradiol + NAD(P)+ = estrone + NAD(P)H + H+ cofactor binding residues are Tyr49, Thr202, Ala50, and Asn51, Theorell-Chance reaction mechanism 675979
Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.6217beta-estradiol + NAD(P)+ = estrone + NAD(P)H + H+ isoforms differs in substrate specificity and tissue distribution, some enzyme forms displays also other activities such as type 4 that acts also as a short chain alcohol dehydrogenase and hydratase and type 10, that is identical to endoplasmic amyloid-beta-binding protein and mitochondrial short chain L-3-hydroxyacyl-CoA dehydrogenase 656654
Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.6217beta-estradiol + NAD(P)+ = estrone + NAD(P)H + H+ ordered bi bi mechanism 287192
Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.6217beta-estradiol + NAD(P)+ = estrone + NAD(P)H + H+ structure-function analysis, dimerization is crucial for catalytic activity 672789
Results 1 - 8 of 8
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