1.1.1.361 | D-glucose 6-phosphate + NAD+ = 3-dehydro-D-glucose 6-phosphate + NADH + H+ |
NtdC follows a random sequential mechanism, consistent with our product inhibition. The equilibrium position of the NtdC-catalyzed reaction greatly favors G6P, and the rate of 3-dehydro-D-glucose 6-phosphate formation at neutral pH is very low, under more favorable basic conditions, the product of the reaction is unstable |
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