EC Number   |
Reaction |
Reference |
|---|
   1.1.1.146 | an 11beta-hydroxysteroid + NADP+ = an 11-oxosteroid + NADPH + H+ |
- |
- |
| 1.1.1.146 | an 11beta-hydroxysteroid + NADP+ = an 11-oxosteroid + NADPH + H+ |
active site variability of isozyme 11beta-HSD1, structure-activity analysis, catalytic mechanism |
670263 |
| 1.1.1.146 | an 11beta-hydroxysteroid + NADP+ = an 11-oxosteroid + NADPH + H+ |
substrate binding and active site structure, isozyme 11beta-HSD1 contains the conserved catalytic motif YSASK, Tyr177 is not a hydrogen bond donor in substrate binding but is involved via hydrophobic interaction, Tyr177 is not involved in determination of substrate specificity |
667835 |
| 1.1.1.146 | an 11beta-hydroxysteroid + NADP+ = an 11-oxosteroid + NADPH + H+ |
substrate binding site structure, reaction mechanism involving Lys187 and Tyr183, active site structure involving a S-Y-K catalytic triad |
667673 |
