EC Number |
Reaction |
Reference |
---|
1.1.1.1 | a primary alcohol + NAD+ = an aldehyde + NADH + H+ |
active site structure |
656525 |
1.1.1.1 | a primary alcohol + NAD+ = an aldehyde + NADH + H+ |
catalytic mechanism involves a proton relay modulated by the coupled ionization of the active site Lys155/Tyr151 pair, and a NAD+ ribose 2'-OH switch, other active site residues are Ser138 and Trp144, ionization properties, substrate binding, overview |
657317 |
1.1.1.1 | a primary alcohol + NAD+ = an aldehyde + NADH + H+ |
class IV alcohol dehydrogenase also functions as retinol dehydrogenase, reaction and kinetic mechanism: asymmetric rapid equilibrium random mechanism with 2 dead-end ternary complexes fro retinol oxidation and a rapid equilibrium ordered mechanism with one dead-end ternary complex for retinal reduction, a unique mechanistic form fro zinc-containing ADH in the medium chain dehydrogenase/reductase superfamily of enzymes |
656058 |
1.1.1.1 | a primary alcohol + NAD+ = an aldehyde + NADH + H+ |
compulsory-order mechanism with the rate-limiting step being the dissociation of the product enzyme-NAD+ complex |
285645 |
1.1.1.1 | a primary alcohol + NAD+ = an aldehyde + NADH + H+ |
detailed determination of the reaction and kinetic mechanisms, active site structure and determination of amino acid residues involved in catalysis, 3 isozymes |
655649 |
1.1.1.1 | a primary alcohol + NAD+ = an aldehyde + NADH + H+ |
isoenzyme EE and SS: ordered bi bi mechanism |
285590 |
1.1.1.1 | a primary alcohol + NAD+ = an aldehyde + NADH + H+ |
kinetic mechanism is random for ethanol oxidation and compulsory ordered for acetaldehyde reduction |
285596 |
1.1.1.1 | a primary alcohol + NAD+ = an aldehyde + NADH + H+ |
mechanism is predominantly ordered with ethanol, but partially random with butanol |
285646 |
1.1.1.1 | a primary alcohol + NAD+ = an aldehyde + NADH + H+ |
ordered bi bi mechanism with cofactor adding first to form a binary enzyme complex |
285578 |
1.1.1.1 | a primary alcohol + NAD+ = an aldehyde + NADH + H+ |
ordered bi-bi mechanism |
285586, 285598 |