  6.2.1.5 | ATP + succinate + CoA = ADP + phosphate + succinyl-CoA |
reaction mechanism, Glu435 is a key active site residue, overview. Class I CoA-transferases first bind the acyl-CoA substrate, forming a carboxylate product and an enzyme-CoA thioester intermediate, which accounts for the observed ping-pong kinetics and susceptibility to borohydride inactivation |
692865 |