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Results 1 - 4 of 4
EC Number
3,4-dihydroxybenzoate + O2 = 3-carboxy-cis,cis-muconate
examining a distorted trigonal-bipyramidal geometry observed for the non-heme iron center in protocatechuate 3,4-dioxygenase by utilizing a sterically hindered iron salen complex gives following results: the extent of a structural change of the iron center from a preferred square-pyramidal to a distorted trigonal-bipyramidal geometry varies with the external ligand that is bound in the order Cl <
3,4-dihydroxybenzoate + O2 = 3-carboxy-cis,cis-muconate
proposed mechanism based on Mössbauer, EPR and inhibition kinetic data
3,4-dihydroxybenzoate + O2 = 3-carboxy-cis,cis-muconate
proposed reaction mechanism
3,4-dihydroxybenzoate + O2 = 3-carboxy-cis,cis-muconate
the computational (hybrid density functional method B3LYP) results of the catalytic cycle of the intradiol dioxygenases suggest: (1)binging of the substrate as a dianion (2) binding of dioxygen to the metal aided by an electron transfer from the substrate to O2 (3) formation of a bridging peroxo intermediate and its conformational change, which opens the coordination site trans to His462, (4) binding of a neutral XOH ligand (H2O or Tyr447) at the open site, (5) proton transfer from XOH to the neighboring peroxo ligand yielding the hydroperoxo intermediate, (6) a Criegee rearrangment leading to the anhydride intermediate (the criegee mechanism requires an in-plane oriantation of the involved two oxygen and two carbon atoms. Under some conditions homolytic O-O bond cleavage might compete with the Criegee rearangment.) and (7) hydrolysis of the anhydride to the final acyclic product.
Results 1 - 4 of 4