1.1.1.270 | a 3beta-hydroxysteroid + NADP+ = a 3-oxosteroid + NADPH + H+ |
residues Leu/Val54, Tyr55, His117, Val128, Ile129, His222, and Trp227 are involved in substrate binding, Tyr55, Asp50, Lys84, and His117 form the catalytic tetrad, Tyr55 and His117 together with NADP+ form an oxyanion hole through hydrogen bond networks, molecular docking simulations, detailed overview |
677144 |