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EC Number
Reaction
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a 3beta-hydroxysteroid + NADP+ = a 3-oxosteroid + NADPH + H+
also acts on 5alpha-cholest-7-en-3-one
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a 3beta-hydroxysteroid + NADP+ = a 3-oxosteroid + NADPH + H+
residues Leu/Val54, Tyr55, His117, Val128, Ile129, His222, and Trp227 are involved in substrate binding, Tyr55, Asp50, Lys84, and His117 form the catalytic tetrad, Tyr55 and His117 together with NADP+ form an oxyanion hole through hydrogen bond networks, molecular docking simulations, detailed overview
a 3beta-hydroxysteroid + NADP+ = a 3-oxosteroid + NADPH + H+
stereoselectivity : #1,4,5# catalyzes reduction of the 3-keto group to a 3beta-hydroxyl group <5,6,7>
Results 1 - 3 of 3