EC Number |
Reaction |
Reference |
---|
1.1.1.103 | L-threonine + NAD+ = L-2-amino-3-oxobutanoate + NADH + H+ |
it is suggested that the unstable L-2-amino-3-oxobutanoate spontaneousely decarboxylates to the stable aminoacetone, there is also some evidence that L-threonine is oxidatively decarboxylated by threonine dehydrogenase to produce aminoacetone |
285713 |
1.1.1.103 | L-threonine + NAD+ = L-2-amino-3-oxobutanoate + NADH + H+ |
ordered bi-bi mechanism, NAD+ binds prior to L-threonine |
-, 655857 |
1.1.1.103 | L-threonine + NAD+ = L-2-amino-3-oxobutanoate + NADH + H+ |
reaction mechanism, random bi bi kinetic mechanism |
-, 668536 |
1.1.1.103 | L-threonine + NAD+ = L-2-amino-3-oxobutanoate + NADH + H+ |
His94 is an active site residue, substrate binding involved residues Gly66, Gly71, Gly77, and Val80 |
668567 |
1.1.1.103 | L-threonine + NAD+ = L-2-amino-3-oxobutanoate + NADH + H+ |
catalytic mechanism, the carboxyl group of Glu152 is important for expressing the catalytic activity, the proton relay system works as a catalytic mechanism of TDH |
687461 |
1.1.1.103 | L-threonine + NAD+ = L-2-amino-3-oxobutanoate + NADH + H+ |
reaction mechanism involving catalytic residues T112, Y137, and K141, overview |
722747 |