EC Number   |
Posttranslational Modification |
Reference |
|---|
   3.4.22.62 | nitrosylation |
nitrosylation of caspase-9 at C163 is dependent, at least in part, on subcellular localization. 68% of the procaspase-9 in mitochondria is nitrosylated and 11% of the procaspase-9 in the cytoplasm in unstimulated 10C9 human B cells |
663674 |
| 3.4.22.62 | phosphoprotein |
caspase-9 is phosphorylated at Thr125 in cells by ERK1/2 but not by c-Jun N-terminal kinases or p38 MAPKs |
680914 |
| 3.4.22.62 | phosphoprotein |
caspase-9 is phosphorylated on Thr125 in a MEK172-dependent manner in vivo, efficiently phosphorylated on Thr125 by ERK in vitro. Phosphorylation of Thr125 on caspase-9 may be an important mechanism through which growth factor and survival signals that activate the ERK MAPK pathway can inhibit apoptosis |
647416 |
| 3.4.22.62 | phosphoprotein |
caspase-9 is regulated during cell cycle through periodic phosphorylation at an inhibitory site, Thr125. This site is phosphorylated by CDK1/cyclin B1 during mitosis and in response to microtubule poisons that arrest cells at this stage of the cell cyclce. Phosphorylation of caspase-9 at Thr125 protects mitoctic cells against apoptosis |
681883 |
| 3.4.22.62 | phosphoprotein |
CPP32 processes pro-Mch6 preferentially at Asp330 to generate two subunits of molecular masses 37000 Da and 10000 Da. Granzyme B can also process pro-Mch6 but at a site N-terminal to that cleaved by CPP32 and generates two cleavage products, a large 35000 Da product and a small 12000 Da product |
647414 |
| 3.4.22.62 | phosphoprotein |
kinase Akt and p21-Ras, an Akt activator, induce phosphorylation of pro-caspase-9 in cells. Akt phosphorylates recombinant caspase-9 in vitro on Ser196 and inhibits its protease activity. Mutant pro-caspase9(Ser196Ala) is resistant to Akt-mediated phosphorylation |
647427 |
| 3.4.22.62 | phosphoprotein |
phophorylation of caspase-9 at the inhibitory threonine residue 125 catalyzed by the protein kinase DYRK1A |
697888 |
| 3.4.22.62 | phosphoprotein |
phophorylation of the inhibitory threonine residue 125, catalyzed by the protein kinase DYRK1A |
697538 |
| 3.4.22.62 | phosphoprotein |
phosphorylation of caspase-9 by casein kinase 2 (CK2) on a serine near the site of caspase-8 cleavage, TNF receptor cross-linking promotes dephosphorylation of caspase-9, phosphorylation of caspase-9 by casein kinase 2 (CK2) decreases its susceptibility to cleavage by active caspase-8 |
698775 |
| 3.4.22.62 | phosphoprotein |
phosphorylation on Ser196 in hypoxic animals increased |
700460 |
