EC Number   |
Posttranslational Modification |
Reference |
|---|
   3.4.21.27 | glycoprotein |
the enzyme bears five N-glycosylation consensus sites per monomer |
732897 |
| 3.4.21.27 | proteolytic modification |
factor XI is activated to factor XIa by site-specific cleavage of zymogen factor XI by thrombin, factor XIIa, or autoactivation |
683756 |
| 3.4.21.27 | proteolytic modification |
factor XI is activated to factor XIIa at 37°C, a conformational transition accompanies conversion of factor XI to factor XIa that conceals the Apple 3 domain zymogen factor XI platelet binding site and exposes the factor XIa platelet binding site within the catalytic domain possibly comprising residues Cys527-Cys542 |
683160 |
| 3.4.21.27 | proteolytic modification |
FXI activation proceeds through an intermediate with one activated subunit, limited digestion by incubating with FXIIa or thrombin |
683682 |
| 3.4.21.27 | proteolytic modification |
the enzyme shows activation by autolysis involving residues of the autolysis loops, overview |
683157 |
| 3.4.21.27 | proteolytic modification |
the zymogen FXI is activated by proteolytic cleavage to FXIa |
684078 |
| 3.4.21.27 | proteolytic modification |
the zymogen is activated by proteolytic cleavage |
683167 |
| 3.4.21.27 | side-chain modification |
glycoprotein, 11% carbohydrate |
36534 |
