EC Number   |
Posttranslational Modification |
Reference |
|---|
   3.4.21.118 | glycoprotein |
enzyme contains N-glycosylation sites |
647327 |
| 3.4.21.118 | glycoprotein |
enzyme has a putative N-glycoslyation site at Asn95 of the kallikrein loop |
647325 |
| 3.4.21.118 | glycoprotein |
KLK8 has one glycosylation site at Asn100 |
717863 |
| 3.4.21.118 | glycoprotein |
N-glycosylated at the kallikrein loop, residues His91-Ile103, oligosacchride chain is essential for activity |
647328 |
| 3.4.21.118 | proteolytic modification |
pro-enzyme may be activiated by lysyl-endopeptidase by cleavage of a 9 amino acid propeptide |
667875 |
| 3.4.21.118 | proteolytic modification |
recombinant enzyme is produced as inactive proform and needs to be processed by an endoprotease, e.g. protease-1, EC 3.4.21.50, or trypsin, EC 3.4.21.4, for activation by specific cleavage of the Lys32-Ile33 bond near the N-terminus |
647323, 647328 |
| 3.4.21.118 | proteolytic modification |
the extra 45 amino acids of KLK8 type II are removed during the enzyme activation process, resulting in the same end-point enzyme as that of type I |
697185 |
