EC Number |
Posttranslational Modification |
Reference |
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1.2.1.31 | more |
homolog of the yeast Lys5 gene encodes alpha-aminoadipate dehydrogenase phosphopantetheinyl transferase activity, 26% identity and 44% similarity to the yeast counterpart |
288202 |
1.2.1.31 | more |
Lys5 demonstrates phosphopantetheinyl transferase activity toward the 14-kDa Lys2 peptidyl carrier protein fragment, with a Km of 0.001 mM and a turnover number of 3/min |
288201 |
1.2.1.31 | more |
specific amino acid residues, namely G882 and S884 of the Lys2p activation domain are required, the phosphopantetheinyl transferase is required for the activation of Lys2p and not for its alpha-aminoadipate reductase activity |
288204 |
1.2.1.31 | side-chain modification |
Lys5 is a specific posttranslational modification catalyst, using coenzyme A as a cosubstrate to phosphopantetheinylate Ser880 of the Lys2 activating it for catalysis |
288201 |
1.2.1.31 | side-chain modification |
the 150-kDa Lys2p is posttranslational modified in the presence of coenzyme A and Candida albicans lys2 mutant extract as a source of phosphopantetheinyl transferase |
288204 |
1.2.1.31 | side-chain modification |
the lys5 gene product is functionally active and can recognize apo-Lys2, transferring a 4'-phosphopantetheinyl moiety to the conserved serine residue in the peptidyl carrier domain of the protein |
288203 |