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EC Number	Application	Commentary	Reference
6.3.1.9	drug development	the enzyme is a target for drug development	661810
6.3.1.9	drug development	the enzyme is a target for drug development for treatment of human African trypanosomiasis caused by Trypanosoma brucei gambiense and rhodesiense	727329
6.3.1.9	drug development	trypanothione synthetase is a validated drug target	-, 727114
6.3.1.9	more	enzyme TRYS is a valuable target for antiparasitic drug development	-, 744964
6.3.1.9	pharmacology	the enzyme would serve as a potential target for antiparasitic chemotherapy	963
6.3.1.9	synthesis	production of trypanothione and trypanothione disulfide in >200 mg quantities by mutant C59A lacking the amidase activity. The protocol also allows the synthesis of related glutathione conjugates	704099

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Release 2023.1 (January 2023)