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EC Number Application Commentary Reference
Display the reaction diagram Show all sequences 6.3.1.4medicine the first intron of the gene ASNS contains two 14-bp tandem repeat sequences, i.e. 2R. Approximately 75% of acute lymphoblastic leukemia samples have the 2R sequence in both alleles, 20% and 3% acute lymphoblastic leukemia samples have three and four 14-bp tandem repeats in one allele, respectively. The other allele has 2R. The tandem repeat sequence is not specific to the leukemia cells but represents a novel germline polymorphism. The 14-bp sequence functions as a transcriptional enhancer element as shown by reporter analysis and forms a protein-DNA complex in vitro 705446
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