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EC Number Application Commentary Reference
Show all pathways known for 3.5.1.38Display the word mapDisplay the reaction diagram Show all sequences 3.5.1.38drug development enzyme could possibly be used as an anti-tumor therapeutic agent -, 687356
Show all pathways known for 3.5.1.38Display the word mapDisplay the reaction diagram Show all sequences 3.5.1.38medicine L-glutaminase has a significant efficiency against Hep-G2 cell (IC50 6.8x02g/ml) and HeLa cells (IC50 8.3 g/ml), while the growth of MCF-7 cells is not affected. L-glutaminase has a moderate cytotoxic effect against HCT-116 cells (IC50 64.7 g/ml) and RAW 264.7 cells (IC50 59.3 g/ml). In vivo, L-glutaminase shows no observed changes in liver, kidney functions, hematological parameters and slight effect on red blood cells and level of platelets after 10 days of rabbit's injection 753129
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