EC Number   |
Application |
Reference |
|---|
   3.4.22.66 | drug development |
the conserved key site of the enzyme may serve as attractive target for the design of broad-spectrum antivirals for multiple viruses in the supercluster |
-, 732410 |
| 3.4.22.66 | medicine |
calicivirus 3CLpro mediates the cleavage of poly(A)-binding protein as part of its strategy to inhibit cellular translation |
-, 670075 |
| 3.4.22.66 | medicine |
establishment of a mammalian cell-based system for analysis of human norovirus replication and, thus makes it feasible to investigate antiviral agents in mammalian cells |
670711 |
| 3.4.22.66 | medicine |
nonbacterial acute gastroenteritis and other diseases associated with viruses expressing 3Cpro, knowledge of the structure and previous mutagenesis study allows to correlate proteolysis and structure |
670082 |
| 3.4.22.66 | medicine |
norovirus precursor comprised of both the proteinase and polymerase (released from 3C-like proteinase) is a bifunctional enzyme during virus replication, which might be useful in the development of antiviral drugs of the noroviruses associated with acute gastroenteritis |
-, 670086 |
| 3.4.22.66 | medicine |
Norwalk virus is the major cause of acute, epidemic, viral gastroenteritis |
670097 |
| 3.4.22.66 | medicine |
poliovirus 3Cpro mediates the cleavage of poly(A)-binding protein as part of its strategy to inhibit cellular translation |
670075 |
