EC Number   |
Application |
Reference |
|---|
   3.4.22.62 | medicine |
analysis of a single nucleotide polymorphism (SNP) in the caspase-9 gene in relation to susceptibility to multiple sclerosis (MS) |
699671 |
| 3.4.22.62 | medicine |
B cell lymphoid malignancies are treated with T cells expressing the chimeric antigen receptor (CAR) specific for the CD19 antigen (CD19.CAR-Ts). The inducible caspase-9 safety switch, i.e. a modified human caspase-9 fused to the human FK506 binding protein, can eliminate CD19.CAR-Ts in a dose-dependent manner, allowing either a selective containment of CD19.CAR-T expansion in case of cytokine release syndrome or complete deletion on demand granting normal B cell reconstitution |
754791 |
| 3.4.22.62 | medicine |
caspase-9 is a target for development of therapeutic approaches for histamine-related diseases |
-, 680763 |
| 3.4.22.62 | medicine |
dysregulation of the apoptotic response in differentiating neurons participates in the neuropathology of diseases that display with an imbalance of DYRK1A gene-dosage |
697538 |
| 3.4.22.62 | medicine |
effectiveness and specificity of an inducible caspase 9-based safety switch system, to halt an ongoing immune attack, reduction of the risk of severe graft-vs-host disease, murine model for cell therapy-induced type I diabetes |
699324 |
| 3.4.22.62 | medicine |
inhibition of the caspase-9 activity would render opportunity to treat patients suffering from neurological diseases such as stroke, neurodegenerative diseases or brain injury caused by hypoxia |
647418 |
| 3.4.22.62 | medicine |
levels of caspase-8 and caspase-9 in sperm and plasma are significantly negatively correlated with sperm concentration, motility and A % (motility grade A). Only in healthy fertile controls sperm concentration is significantly negatively correlated with caspase-9 in sperm. Caspase-8 and caspase-9 in sperm and plasma are correlated with sperm motility, and can reflect the quality of sperm in vitro |
753880 |
| 3.4.22.62 | medicine |
mechanisms of adenosine-induced apoptosis in human colonic cancer cells |
699289 |
| 3.4.22.62 | medicine |
there is a weak correlation between activated caspase-9 and poor neurologic outcome after severe traumatic brain injury |
710088 |
| 3.4.22.62 | pharmacology |
analysis and improvement of apoptosome inhibitors |
699440 |
