EC Number |
Application |
Reference |
---|
3.4.22.49 | diagnostics |
measurement of separase proteolytic activity in single living cells by a fluorogenic flow cytometry assay. The assay is used to quantify Separase proteolytic activity in leukemic cell lines and peripheral blood samples from leukemia patients |
755097 |
3.4.22.49 | medicine |
due to the oncogenic activity of cohesin protease, separase in human cancer cells, modulation of separase enzymatic activity could constitute a new therapeutic strategy for targeting resistant, separase-overexpressing aneuploid tumors |
752988 |
3.4.22.49 | medicine |
the results show that separase might be a tumor supressor gene |
680013 |
3.4.22.49 | molecular biology |
data suggest that the co-ordinated expression of separase, securin and Rad21 is fundamental for the developing brain |
681037 |
3.4.22.49 | molecular biology |
in Saccharomyces cerevisiae separase it is shown that separase is implicated in a second non-proteolytic pathway: separsae is essential for the activation of Cdc14 phosphatase and thus a broad programme of late mitotic events culminating in mitotic exit and cell division |
682065 |
3.4.22.49 | molecular biology |
separase is identified as a key cell cycle component that is required for degranulation |
679433 |
3.4.22.49 | molecular biology |
separse is not only required for chromosome segregation but also for meiotic exit |
682065 |
3.4.22.49 | molecular biology |
the results indicate that inhibitory phosphorylation of separase plays a critical role in the maintenance of sister chromatid cohesion and genome stability in proliferating postmigratory primordial germ cells |
682481 |
3.4.22.49 | molecular biology |
the results show that a fraction of arm cohesin is protected by Sgo1, which prevents cohesin from being removed by the prophase pathway, and that separase is partly activated in nocodazole-arrested cells and removes the arm cohesion protected by Sgo1 |
681015 |