EC Number   |
Application |
Reference |
|---|
   3.4.21.B26 | medicine |
av endoproteolytic activation is necessary for integrin-mediated adhesion and migration as well as signaling and requires PC5 in vascular smooth muscle cells |
673108 |
| 3.4.21.B26 | medicine |
carotid atherosclerotic lesions obtained by endaterectomy contain PC5, PC5 colocalizes with av integrin |
673108 |
| 3.4.21.B26 | medicine |
crucial role in heart development and in endothelial cells, involved in embryonic bone morphogenesis |
673910 |
| 3.4.21.B26 | medicine |
crucial role in prorenin activation within the adrenal cortex or in HIV gp160 processing in CD4+ cells, major impact on cellular proliferation and on sexual differentiation, involvement in food metabolism |
673910 |
| 3.4.21.B26 | medicine |
PC5 is a potential contributor to the initiation, progression, and complications of atherosclerosis and restenosis, targeting PC5 will likely provide novel anti-atherosclerosis strategies |
675490 |
| 3.4.21.B26 | medicine |
PC5/6 plays a key role for decidualization in human endometrium and its action is necessary for prolactin production from endometrial stromal cells |
675051 |
| 3.4.21.B26 | medicine |
PC5/6A is involved in squamous differentiation of human nasal epithelial cells, possibly through up-regulation of the BMP-2/pSmad1/5/8/p38 signaling pathway, pointing to a potential therapeutic target for the prevention of chronic airway diseases that exhibit squamous metaplasia |
752449 |
