EC Number   |
Application |
Reference |
|---|
   3.4.21.104 | diagnostics |
MASP-2 may have potential as clinical biomarkers in colorectal cancer |
684060 |
| 3.4.21.104 | medicine |
evaluation of the role of MASP-2 in HIV infection. The MASP-2 .126L variant is associated with MASP-2 levels <200 ng/ml and increases the susceptibility to HIV infection and to HIV plus hepatitis B virus positive status. p.126L in addition to other variants associated with low MASP-2 levels such as p.120G, p.377A and p.439H, presents a protective effect against AIDS, independently of age, sex, hepatic function andviral load. MASP-2 serum levels are lower in HIV positive and HIV plus hepatitis B virus positive patients than in controls. Among patients, MASP-2 levels are higher in patients with opportunistic diseases and AIDS. MASP-2 levels correlate positively with MBL/MASP2-mediated complement component C4 and negatively with CD4+ cell counts |
754751 |
| 3.4.21.104 | medicine |
it is investigated whether the concentration of mannose-binding lectin and MASP-2 is associated with prognosis in pediatric patients with cancer. In the 372 patients studied, median serum concentration of mannose-binding lectin (MBL) is 2.808 mg/l and 391 mg/l for MASP-2. The estimated 4-year event-free survival is 0.60. In the entire, heterogeneous sample, MBL and MASP-2 are not significantly associated with overall survival or event-free survival. In patients with hematologic malignancies, higher MASP-2 is associated with better event-free survival in a significant and clinically relevant way. This is due to patients with lymphoma, but less for those with acute leukemia |
700576 |
| 3.4.21.104 | medicine |
MASP-2 serum levels vary between younger children (12 years and less) and older children (above 12 years) and adults. Younger children with a patent infection with with Schistosoma haematobium have significantly lower MASP-2 serum levels than uninfected children. Older children and adults with a current infection have higher serum MASP-2 levels than controls. mannose-binding lectin serum levels correlate positively with MASP-2 serum levels. MASP2 secretor haplotypes are associated with MASP-2 serum levels in healthy subjects. The heterozygous MASP2 P126L variant is associated with reduced serum MASP-2 levels |
755621 |
| 3.4.21.104 | medicine |
proteases MASP-1 and MASP-2 levels are significantly higher in children and adults with type 1 diabetes mellitus than in their respective control groups, whereas proteases MASP-3 and MAp44 levels do not differ between patients and controls. MASP-1 and MASP-2 levels correlate with hemoglobin HbA1c, and MASP levels decrease when glycaemic control improves |
753309 |
| 3.4.21.104 | molecular biology |
near monodisperse endotoxin-free polyethylene glycol, at concentrations relevant to therapeutic effects, trigger complement activation in human sera. Depending on polyethylene glycol concentration and average molecular weight, complement activation proceeds either exclusively through MASP-2 activation, and a likely role for the lectin pathway, or through both MASP-2-mediated C4 cleavage and accelerated alternative pathway turnover |
700248 |
