EC Number   |
Application |
Reference |
|---|
   3.2.1.143 | analysis |
non-radioactive and quantitative assay system for PARG activity based on dot-blot assay using anti-poly(ADP-ribose) and nitrocellulose membrane. The maximum velocity Vmax and the Michaelis constant Km of PARG reaction according to this method are 4.46 microM and 128.33 micromol/min/mg, respectively |
707395 |
| 3.2.1.143 | drug development |
DNA damage repair enzymes, including the enzyme poly(ADP-ribose) glycohydrolase (PARG), are promising targets in the development of therapeutic agents for a wide range of cancers and potentially other diseases |
754393 |
| 3.2.1.143 | drug development |
inhibitors of the enzyme are potent anticancer drug candidates |
731260 |
| 3.2.1.143 | drug development |
single treatment therapy with PARG inhibitors can be used for treatment of certain homologous recombination-deficient tumours |
753397 |
| 3.2.1.143 | drug development |
the enzyme is a target for development of specific inhibitors |
732776 |
| 3.2.1.143 | drug development |
the enzyme is a target for drug design |
732714 |
| 3.2.1.143 | drug development |
the protozoan enzyme represents a good model for human PARG and is therefore likely to prove useful in guiding structure-based discovery of new classes of PARG inhibitors |
732568 |
| 3.2.1.143 | medicine |
DNA repair factor XRCC1 is involved in regulating a poly(ADP-ribose)-mediated apoptotic cell death |
680710 |
| 3.2.1.143 | medicine |
enzyme activity modulates the inflammatory response and tissue events associated with spinal cord trauma and participates in target organ damage under these conditions |
681574 |
| 3.2.1.143 | medicine |
since combination of poly(ADP-ribose) polymerase-1 and poly(ADP-ribose) glycohydrolase inhibition in chemotherapy does not produce increased HeLa cell death, strategies that target poly(ADP-ribose) metabolism for the improved treatment of cancer may be required to target poly(ADP-ribose) polymerase-1 and poly(ADP-ribose) glycohydrolase individually in order to optimize cancer cell death |
731955 |
