EC Number   |
Application |
Reference |
|---|
   3.1.3.67 | analysis |
availability of the phosphorylated and unphosphorylated forms of recombinant PTEN permits future investigations into the three-dimensional structures of the phosphorylated and unphosphorylated forms of PTEN, and the role of phosphorylation in regulating PTEN activity, phospholipid- and protein-binding affinities |
682679 |
| 3.1.3.67 | diagnostics |
putative biomarker, nuclear localization of PTEN is important for intestinal differentiation of gastric carcinomas, the loss of cytoplasmatic PTEN expression is correlated with poor gastric carcinoma prognosis |
691598 |
| 3.1.3.67 | drug development |
This study is a direct evidence for a model in which PTEN switches between open and closed states and phosphorylation favors the closed conformation, thereby regulating localization and function. Small molecules targeting these interactions can potentially serve as therapeutic agents in antagonizing Ras or phosphoinositide 3-kinase-driven tumors. |
694916 |
| 3.1.3.67 | medicine |
paeonol effectively enhances the sensitivity of ovarian cancer cells to radiation by significantly altering regulation of the proteins of the PI3K/Akt pathway, in addition to downregulating VEGF and HIF-1alpha |
750493 |
| 3.1.3.67 | medicine |
PTEN plays an important role in insulin-dependent signaling pathways controlling glucose and lipid metabolsim in vivo. A fine tuning of PTEN expression/activation in target organs is likely to be beneficial to correct metabolic dysfunctions in pathological conditions such as insulin resistance diabetes melitus and obesity |
677869 |
| 3.1.3.67 | medicine |
results demonstrate an important role of PTEN in long term depression and suggest that alterations in PTEN can have an impact on learning and memory process |
682123 |
