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EC Number Application Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.1.1.89medicine in a xenograft model of endometrial cancer, covalent PME-1 inhibitors decrease cell proliferation and invasive growth in vitro but have no effect in vivo at the concentrations tested. Depletion of PME-1 with shRNA in an endometrial cancer xenograft model significantly reduces tumor growth 752312
Display the word mapDisplay the reaction diagram Show all sequences 3.1.1.89medicine no difference in methylation of substrate PP2A catalytic subunit at residue Leu-309 in nonischemic heart failure samples compared with non-failing heart, and no statistical difference in expression of enzyme in ischemic and non-ischemic human heart failure samples compared with non-failing heart tissue 722804
Display the word mapDisplay the reaction diagram Show all sequences 3.1.1.89pharmacology RNAi and pharmacologic inhibition of PME-1 in vitro leads to decreased cell proliferation and invasive growth in endometrial cancer cells. Discovery of more potent PME-1 inhibitors may be beneficial for the treatment of endometrial cancer 752312
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