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Results 1 - 9 of 9
EC Number Application Commentary Reference
Show all pathways known for 2.7.7.60Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.60analysis CTP:phosphocholine cytidylyltransferase enzyme assay that employs separation of non-radioactive 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol from CTP. The assay can be applied to glycerol 3-phosphate cytidylyltransferase and CTP:2-C-methyl-D-erythritol-4-phosphate cytidylyltransferase synthetase (CMS), members of the cytidylyltransferase family that produce CDP-glycerol and CDP-methylerythritol, respectively 737438
Show all pathways known for 2.7.7.60Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.60biotechnology high-throughput methods for the screening of 2C-methyl-D-erythritol synthase IspC protein, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase IspD protein, 4-diphosphocytidyl-2Cmethyl-D-erythritol kinase IspE protein, and 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase IspF protein, against large compound libraries. Assays use up to three auxiliary enzymes monitored at 340 and all robust 675583
Show all pathways known for 2.7.7.60Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.60drug development 2-C-methyl-D-erythritol 4-phosphate cytidyltransferase, enzyme IspD, is a potential therapeutic drug target in Plasmodium vivax -, 761199
Show all pathways known for 2.7.7.60Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.60drug development due to the absence of the pathway in mammals enzyme provides a potential target for new antibiotics 660578, 660697
Show all pathways known for 2.7.7.60Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.60drug development insights in structure and function of MtIspD -, 692926
Show all pathways known for 2.7.7.60Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.60drug development IspD is a druggable target for the development of additional antimalarial agents. 1R,3S-MMV008138 shows promise as a potential scaffold for target-based antimalarial drug development 760261
Show all pathways known for 2.7.7.60Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.60drug development PfIspD enzyme inhibitor MMV008138 does not target the human IspD, reinforcing MMV008138 as a prototype of a distinct class of species-selective IspD-targeting antimalarial agents 760263
Show all pathways known for 2.7.7.60Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.60drug development the methyl erythritol phosphate (MEP) pathway, including enzyme MEP cytidylyltransferase (IspD), represents an attractive series of targets for antibiotic design, considering each enzyme of the pathway is both essential and has no human homologues -, 760333
Show all pathways known for 2.7.7.60Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.60medicine the structure of CMS of Mycobacterium tuberculosis could be a starting point for structure-based design of new antituberculosis drugs -, 705229
Results 1 - 9 of 9