    2.7.1.4 | medicine |
wild-type mice that receive delayed hydration develop renal injury, with elevated serum creatinine, increased urinary neutrophil gelatinase-associated lipocalin, proximal tubular injury, and renal inflammation and fibrosis. This is associated with activation of the polyol pathway, with increased renal cortical sorbitol and fructose levels. Fructokinase-knockout mice with delayed hydration are protected from renal injury. Access to sufficient water during the dehydration period can protect mice from developing renal injury. Studies provide a potential mechanism for Mesoamerican nephropathy |
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