EC Number   |
Application |
Reference |
|---|
    2.4.2.9 | analysis |
biosynthetic labeling of RNA with uracil phosphoribosyltransferase allows cell-specific microarray analysis of mRNA synthesis and decay |
659984 |
| 2.4.2.9 | medicine |
combination of 5-flurocytosine/cytosine deaminase-uracil phosphoribosyltransferase with curcumin can be a potential chemosensitization strategy for cancer treatment |
688919 |
| 2.4.2.9 | medicine |
enzyme is a possible therapeutic target |
638367 |
| 2.4.2.9 | medicine |
in presence of 5-fluorocytosine, rat glioblastoma cells C6 and C6r5-FU are sensitive to the cytotoxic effect of human adipose tissue-derived mesenchymal stem cells expressing yeast cytosinedeaminase::uracil phosphoribosyltransferase. The stem cells migrate to glioblastoma cells in vivo and mediate inhibition of glioblastoma growth |
722407 |
| 2.4.2.9 | medicine |
increased expression of UPRT may improve the antitumoral effect of 5-fluorouracil and 5-fluorocytosine, and thereby enhance the potential gene-directed enzyme prodrug therapy |
684230 |
| 2.4.2.9 | medicine |
the CD/UPRT construct confers 5-fluorocytosine sensitivity to some pancreatic cell lines |
689317 |
| 2.4.2.9 | medicine |
the efficiacy of 5-fluorouracil-based chemotherapy in prostate cancers can be significantly improved by targeted expression of the suicide gene UPRT under the control of the human prostate-specific membrane antigen promotor/enhancer |
689850 |
| 2.4.2.9 | medicine |
the enzyme augments the cancer treatment efficacy of 5-fluorouracil in vitro |
736257 |
| 2.4.2.9 | medicine |
the enzyme increases the sensitivity to 5-fluorouracil in HaP-T1 cells in vitro |
736258 |
| 2.4.2.9 | molecular biology |
engineering the yeast fluorocytosine deaminase (FCY1) gene by creating a fusion with the bacterial uracil phosphoribosyl transferase (UPP) gene results in a recombinant protein that converts the precursor 5-fluorocytosine (5-FC) into 5-fluorouracyl, a drug used in the treatment of a range of cancers, which triggers DNA and RNA damage. The tissue-specific FCY-UPP system is a great tool to inactivate cells in a precise spatial and temporal manner, method evaluation, overview |
755036 |
