EC Number   |
Application |
Reference |
|---|
   2.4.1.68 | medicine |
enzyme of blood platelets is a diagnostic marker for the ploidy level of megakaryocytes in thrombocytopenia |
489338 |
| 2.4.1.68 | medicine |
serum alpha1-6-fucosylated alpha-fetoprotein is employed for an early diagnosis of patients with hepatoma and hepatic disease |
489339 |
| 2.4.1.68 | medicine |
the enzymatic product of core alpha1,6-fucosyltransferase plays a major role in a plethora of pathological conditions, e.g. in prognosis of hepatocellular carcinoma and in colon cancer |
721723 |
| 2.4.1.68 | medicine |
the enzyme is a candidate for the earliest marker of megakaryocyte-commitment in cultured hematopoietic stem cells. Such a marker should allow an earlier detection and earlier transplantation of patients own, ex vivo expanded, megakaryocyte progenitors |
658418 |
| 2.4.1.68 | synthesis |
mutants of the general acid/base residue E274, including E274A, E274S, and E274G, act as efficient glycoligases able to fucosylate a wide variety of complex N-glycopeptides and intact glycoproteins by using alpha-fucosyl fluoride as a simple donor substrate. The alpha-1,6-fucosidase mutants can introduce an alpha1,6-fucose moiety specifically at the Asn-linked GlcNAc moiety to GlcNAc-peptide, and also to high-mannose and complex type N-glycans in the context of N-glycopeptides, N-glycoproteins, and intact antibodies |
-, 757065 |
