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Results 1 - 9 of 9
EC Number Application Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.22analysis development of a MGAT enzymatic assay of human intestinal microsomes using a high-throughput mass spectrometry-based detection system 758472
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.22analysis development of LC/ESI/MS/MS-based fat absorption assay using 1-oleoyl-glycerol-d5 and U13C-triglyceride to assess the ability of MGAT2 inhibitors to inhibit fat absorption in CD1 mice by a meal tolerance test 755776
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.22drug development [acyl CoA]monoacylglycerol acyltransferase 2 (MGAT2) is of interest as a target for therapeutic treatment of diabetes, obesity and other diseases which together constitute the metabolic syndrome 735755
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.22medicine enzyme deficiency protects mice from metabolic disorders (obesity, glucose intolerance, hypercholesterolemia, and fatty liver) despite high-fat diet, caloric intake is normal and dietary fat is absorbed fully but entry into the circulation is reduced, enzyme may be useful target to treat obesity and other metabolic diseases associated with excessive fat intake 705856
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.22medicine enzyme expression is not affected during diabetes, while total intestinal activity is significantly increased. Up-regulation of both enzyme expression and activity in animals fed with high fat diet 659335
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.22medicine expression of MGAT1 is robustly induced during adipocyte differentiation and its expression is suppressed in fat of genetically-obese mice 757377
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.22medicine expression of MGAT1 is robustly induced during adipocyte differentiation and its expression is suppressed in metabolically abnormal obese human subjects 757377
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.22medicine selective inhibition may provide a novel treatment for obesity and its related metabolic complications, defective triacylglycerol synthesis and storage can lead to severe insulin resistance, excess triacylglycerol accumulation leads to obesity, ectopic storage in nonadipose tissues such as liver and skeletal muscle is associated with insulin resistance 701625
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.22pharmacology [acyl CoA]monoacylglycerol acyltransferase 2 (MGAT2) is of interest as a target for therapeutic treatment of diabetes, obesity and other diseases which together constitute the metabolic syndrome 735755
Results 1 - 9 of 9