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Results 1 - 6 of 6
EC Number Application Commentary Reference
Show all pathways known for 2.1.1.28Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.28analysis enzyme serves as a marker for tissues and cells producing epinephrine 639452
Show all pathways known for 2.1.1.28Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.28analysis method to measure tissue contents and activity of phenylethanolamine N-methyltransferase, utilizing double stable isotope ultra performance liquid chromatography-tandem mass spectrometry. The method is based on measurement of deuterium-labeled epinephrine produced from reaction of norepinephrine with deuterium-labeled S-adenosyl-Lmethionine as the methyl donor. In addition to enzyme activity the method allows for determination of tissue contents of PNMT using human recombinant enzyme for calibration. The calibration curve for epinephrine is linear over the range of 0.1 to 5000 pM, with 0.5 pM epinephrine representing the lower limit of quantification 733076
Show all pathways known for 2.1.1.28Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.28medicine strong relationship between PNMT gene expression and tissue epinephrine levels in human pheochromocytomas 733076
Show all pathways known for 2.1.1.28Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.28more a potent inhibitor of phenylethanolamine N-methyltransferase, which exhibits a minimal affinity for the alpha-adrenoceptor, would be a useful pharmacological tool for clearly defining the connection between central epinephrine concentrations and blood pressure. 675306
Show all pathways known for 2.1.1.28Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.28more a potent inhibitor of phenylethanolamine N-methyltransferase, which exhibits minimal affinity for the alpha2-adrenoceptor and is able to cross the brain-blood-barrier, would be a useful pharmacological tool for defining the role of epinephrine in the central nervous systhem. 672557
Show all pathways known for 2.1.1.28Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.28more selective inhibitors of phenylethanolamine N-methyltransferase would be useful pharmacological tools for clearly defining the connection between central epinephrine concentrations and peripheral blood pressure 675297
Results 1 - 6 of 6