EC Number   |
Application |
Reference |
|---|
  2.1.1.1 | analysis |
development of a NNMT activity assay using ultra-high-performance hydrophilic interaction chromatography. It allows for rapid separation of the reaction products, coupled with quadrupole time-of-flight mass spectrometric detection for enhanced sensitivity and enabling high-throughput sample analysis |
758793 |
| 2.1.1.1 | diagnostics |
high enzyme expression levels in oral squamous cell carcinoma cells indicates a favourable prognosis in patients, whereas the absence of NNMT expression constitutes a hallmark of aggressive biological behaviour |
703943 |
| 2.1.1.1 | diagnostics |
NNMT is useful as a biomarker of lung cancer, stages I-III. The sensitivity of the detection in non-small cell lung cancer cells at 90% specficity increases from 25% to 32% when NNMT is used in combination with carcinoembryonic antigen, method development, overview |
704775 |
| 2.1.1.1 | diagnostics |
the enzyme may serve as a potential biomarker for tumor diagnosis and a therapeutic target |
733636 |
| 2.1.1.1 | drug development |
the enzyme might be a good molecular target for lung cancer therapy |
733449, 733618 |
| 2.1.1.1 | medicine |
down-regulation of NNMT in colorectal cancer HT-29 cells diminishes 5-fluorouracil resistance, while overexpression of NNMT in SW-480 cells enhances it |
757887 |
| 2.1.1.1 | medicine |
enzyme activity correlates with tumor growth and morphological changes resembling apoptosis |
441257 |
| 2.1.1.1 | medicine |
enzyme protein level is significantly elevated in younger patients with Parkinson's disease |
441259 |
| 2.1.1.1 | medicine |
epidemiologic study to analyze risk factors for complex congenital heart defects (CHDs) and multifactorial aetiology |
686485 |
| 2.1.1.1 | medicine |
expression of enzyme is significantly higher in cerebellum of patients with idiopathic Parkinson's disease than in control groups |
662956 |
