EC Number   |
Application |
Reference |
|---|
   1.3.1.6 | drug development |
lack of NADH-fumarate reductase in mammalian cells provides an interesting target against Chagas disease |
699012 |
| 1.3.1.6 | medicine |
aurones and auronols can be used as antiprotozoal compounds because the kill intracellularly persisting amastigozyte of Leishmania major by inhibiting respiratory function of parasite mitochondria |
657430 |
| 1.3.1.6 | medicine |
might serve as target for anti-Leishmania drugs |
390842, 390843 |
| 1.3.1.6 | medicine |
pyrvinium pamoate has an anti-cancer effect within tumour-mimicking microenvironments. Pyrvinium pamoate inhibits NADH-fumarate reductase activities in both parasites and mammalian mitochondria and increases the activity of complex II, succinate-ubiquinone reductase, which is part of fumarate reductase, in mitochondria from human cancer cells cultured under normoxia-normoglycemic conditions but not under hypoxia-hypoglycemic conditions |
725318 |
| 1.3.1.6 | medicine |
the enzyme is a target in anticancer therapy |
710873 |
