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Results 1 - 9 of 9
EC Number Application Commentary Reference
Show all pathways known for 1.3.1.2Display the word mapDisplay the reaction diagram Show all sequences 1.3.1.2analysis study on DPD enzyme expression using RT-PCR, immunohistochemistry, enzymatic activity and ELISA. Highest correlation is observed between protein expression measured by ELISA and enzyme activity, correlation of gene expression and ELISA is also significant 700526
Show all pathways known for 1.3.1.2Display the word mapDisplay the reaction diagram Show all sequences 1.3.1.2drug development the enzyme is an adjunct target in cancer therapy since it rapidly breaks down the anti-cancer drug 5-fluorouracil and related compounds 711309
Show all pathways known for 1.3.1.2Display the word mapDisplay the reaction diagram Show all sequences 1.3.1.2medicine development of a HPLC method, sufficient, accurate, fast and sensitive to be applied to the analysis of 5-fluorouracil and 5-fluoro-5,6-dihydrouracil in plasma and cytoplasmic samples, allowing accurate pharmacokinetic analyses and measurements of dihydropyrimidine dehydrogenase in patients who are candidates for fluoropyrimidine-based chemotherapy without the need of a labeled substrate for enzyme studies 670929
Show all pathways known for 1.3.1.2Display the word mapDisplay the reaction diagram Show all sequences 1.3.1.2medicine identification of mutants G366A and T768K in healthy Japanese volunteers. G366A results in marked decrease in enzyme affinity to NADPH, reduction of Vmax for 5-fluorouracil degrading activity, T768K leads to rapid loss of enzyme activity 673116
Show all pathways known for 1.3.1.2Display the word mapDisplay the reaction diagram Show all sequences 1.3.1.2medicine identification of mutations E244V and A551T and splice site mutation IVS11+1G to T in patients with complete loss of enzymic activity 672471
Show all pathways known for 1.3.1.2Display the word mapDisplay the reaction diagram Show all sequences 1.3.1.2medicine rate limiting enzyme for detoxification of exogenous fluoropyrimidines, antitumor drug design 349213, 349220
Show all pathways known for 1.3.1.2Display the word mapDisplay the reaction diagram Show all sequences 1.3.1.2medicine rate limiting enzyme in catabolic degradation of pyrimidine derivatives, selective inhibition is strategy for design of antitumor, antimicrobial and potentially antiparasitic agents 349218
Show all pathways known for 1.3.1.2Display the word mapDisplay the reaction diagram Show all sequences 1.3.1.2medicine target for inhibitor design to enhance the cytotoxical effect of 5-fluorouracil in tumor cells by inhibiting the DPD activity with 5-fluorouracil as substrate 349142, 349143, 349235
Show all pathways known for 1.3.1.2Display the word mapDisplay the reaction diagram Show all sequences 1.3.1.2medicine uracil breath test breath 13CO2 pharmacokinetics parallel plasma [2-13C]uracil and [2-13C]dihydrouracil pharmacokinetics and are an accurate measure of interindividual variation in enzyme activity. Data support the use of uracil breath test to identify enzyme deficiency before 5-fluorouracil-based therapy 673121
Results 1 - 9 of 9