EC Number   |
Application |
Reference |
|---|
   1.21.99.4 | medicine |
Dio2 plays a significant role in the photoperiodic response of gonads, melatonin is involved in the signal transduction mechanisms controlling the photoperiodic response of gonads by acting on Dio2 expression |
686406 |
| 1.21.99.4 | medicine |
exposure of animals to ventilator-induced lung injury leads to ignificant increases in enzyme immunorectivity and activity. Treatment of knock-out mice with 3,3',5-triiodothyronine reverses many of the lung chemokine and cytokine profiles seen in response to ventilator-induced lung injury |
728674 |
| 1.21.99.4 | medicine |
expression and alternative splicing of DIO mRNA is disturbed in renal cancer, possibly due to changes in expression of splicing factors SF2/ASF and hnRNPA1 |
701298 |
| 1.21.99.4 | medicine |
expression and function of the 5-deiodinase and 5-deiodinase isozymes are sensitive to thyroid hormone status, various cytokines and growth factors, severe illness, reactive oxygen species, a variety of hormones and signaling compounds, circadian rythm, and pharmacological agents, and therefore might be useful in sensor function of physiology and pathophysiology |
644806 |
| 1.21.99.4 | medicine |
the enzymatic activity of isoform Dio1 is not significantly altered in focal nodular hyperplasia and hepatocellular carcinomas when compared to matched normal liver parenchyma controls |
733218 |
| 1.21.99.4 | medicine |
thyroglobulin gene mutations induce defective intracellular transport of thyroglobulin leading to increased thyroidal type 2 iodothyronine deiodinase activity, increased thyroidal type 2 deiodinase activity accounts for a relatively high serum free T3 level with a disproportionately low serum free T4 level |
687956 |
| 1.21.99.4 | more |
food restriction leads to reduced liver type 1 deiodinase activity, administration of 3,3,5,5-tetraiodo-L-thyronine restores type 1 deiodinase activity and promotes body protein loss |
688011 |
| 1.21.99.4 | more |
type 2 deiodinase is inactivated via WSB-1 mediated ubiquination but can be rescued from proteasomal degradation by USP-33 mediated deubiquination, expression of WSB-1 and USP-33 underlie cell specific posttranslational control of type 2 deiodinase |
686409 |
