EC Number   |
Application |
Reference |
|---|
   1.2.4.4 | medicine |
activation of the BCKDH complex appears responsible for the increase in branched-chain amino acid catabolism caused by exercise and liver cirrhosis, branched-chain amino acid administration improves protein turnover in humans with liver cirrhosis, suggesting that branched-chain amino acid supplements are appropriate for patients with liver cirrhosis, branched-chain amino acid administration in patients with acute liver failure, especially those with high serum branched-chain amino acid concentrations, may not be appropriate because of the likelihood of branched-chain amino acid overload |
675567 |
| 1.2.4.4 | medicine |
activation of the BCKDH complex appears responsible for the increase in branched-chain amino acid catabolism caused by exercise and liver cirrhosis, branched-chain amino acid administration improves protein turnover in rats with liver cirrhosis, suggesting that branched-chain amino acid supplements are appropriate for patients with liver cirrhosis |
675567 |
| 1.2.4.4 | medicine |
in male rats administered with 4 doses of 5-FU, 150 mg/kg b.wt. each, 5-FU treatment causes an increase in branched-chain alpha-keto acid dehydrogenase complex BCKDH activity that results mainly from increased dephosphorylation of the complex and is associated with an increase of phosphatase PPM1K mRNA level and reduction of BDK and dehydrogenase E1 mRNA levels |
763049 |
| 1.2.4.4 | medicine |
variations in the gene of branched-chain alpha-keto acid dehydrogenase are associated with the occurrence of premature ovarian failure |
686828 |
| 1.2.4.4 | more |
activation of the translational regulators by leucine is partly regulated by the activity of BCKDH complex |
671751 |
| 1.2.4.4 | more |
NMR techniques to determine the structure of hbSBD and dynamics of several truncated constructs from the E2 component, including hbLBD (residues 184), hbSBD (residues 111149), and a di-domain (hbDD) (residues 1166) comprising hbLBD, hbSBD and the interdomain linker, the presence of the interdomain linker restricts the motional freedom of the hbSBD more significantly than hbLBD, the linker region likely exists as a soft rod rather than a flexible string in solution |
674648 |
| 1.2.4.4 | more |
regulation of BCKD kinase expression by nutritional, hormonal, and pathological factors |
675563 |
| 1.2.4.4 | more |
use of a microRNA to exert control on a metabolic pathway of amino acid catabolism |
673938 |
| 1.2.4.4 | synthesis |
functional expression of the branched chain alpha-keto acid dehydrogenase complex in Escherichia coli by independent and selective optimization of individual subunit genes of the complex. Codon optimization significantly improves the expression of complex component proteins BkdH and LpdA1 but expression of dehydrogenase E1 alpha subunit BkdF and dehydrogenase E1 beta subunit BkdG depends on coexpression of the BkdH gene. The optimized branched chain alpha-keto acid dehydrogenase complex supplies sufficient short branched-chain acyl-CoA to synthesize phlorisovalerophenone |
762852 |
