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EC Number Application Commentary Reference
Display the reaction diagram Show all sequences 1.14.99.61synthesis CotB3 can be employed to functionalize other diterpene olefins, such as (-)-casbene to yield sinularcasbane D 748588
Display the reaction diagram Show all sequences 1.14.99.61synthesis efficient heterologous reconstitution of the cyclooctatin biosynthesis cluster by introduction of a novel, non-native Streptomyces-derived redox system (reductase/ferredoxin system from Streptomyces afghaniensis). The complete, heterologous biosynthesis cascade is established in Escherichia coli. The microbial production system allows for a 43fold increased cyclooctatin yield compared to the native producer Streptomyces melanosporofaciens 748588
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