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1.14.15.18
medicine
genes CYP2R1 encoding vitamin D 25-hydroxylase, CYP27B1 encoding 25-hydroxyvitamin D-1 alpha hydroxylase and CYP24A1 encoding 1,25-dihydroxyvitamin D(3) 24-hydroxylase are upregulated in clear cell renal cell carcinomas compared with normal tissue. CYP24A1 displays a significantly higher expression in tumors than CYP27B1 and CYP2R1, whereas no differences in the expression of these genes are found in healthy renal tissue. Gene expression of CYP2R1, CYP27B1 and CYP24A does not differ between pathological classifications
724907
1.14.15.18
medicine
hyperplastic parathyroid glands from patients with chronic kidney failure normally display a heterogeneous cellularity. 25-hydroxyvitamin D3 1alpha-hydroxylase is expressed at much higher levels in oxyphil cells than in chief cells in these patients. The calcimimetic cinacalcet increases the expression of the enzyme in human parathyroid cultures. The enzyme in human parathyroid cultures is functionally active
725826
1.14.15.18
medicine
the enzyme is a target in cancer therapy and prevention
675686
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