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EC Number Application Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 1.14.14.80medicine hepatic CYP4A14 expression is up-regulated in three murine models of nonalcoholic fatty liver disease. Overexpression of CYP4A14 in the livers of C57BL/6 mice results in a fatty liver phenotype with a significant increase in hepatic fatty acid translocase (FAT/CD36) expression. CYP4A14 gene-deficient mice fed a high-fat diet or a methionine and choline-deficient diet exhibit attenuated liver lipid accumulation and reduced hepatic FAT/CD36 expression. Hepatic inflammation and fibrosis is markedly ameliorated in methionine and choline-deficient diet-fed CYP4A14-deficient mice 746320
Display the word mapDisplay the reaction diagram Show all sequences 1.14.14.80medicine specific inhibition of either the CYP2C epoxygenase or the CYP4A omega-hydroxylase abrogates peroxisomal proliferation induced by the hypolipidemic drug cirpofibrate 734431
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