EC Number   |
Application |
Reference |
|---|
    1.14.14.17 | biotechnology |
genetic manipulation of the ERG1 gene is a promising tool for increasing squalene production in yeast |
-, 727560 |
| 1.14.14.17 | drug development |
possible enzyme to inhibit for treatment of hypercholesterolemia, but strong side effects (e.g. dermatitis-like toxicity) |
697143 |
| 1.14.14.17 | medicine |
breast, ovarian, and colorectal cancers show the highest copy number-driven gene expression among 8783 cases from 22 cancer types, with breast camcer presenting the strongest one. Squalene epoxidase overexpression is more prevalent in aggressive breast cancer, and is an independent prognostic factor of unfavorable outcome. Squalene epoxidase inhibition results in a copy-dosage correlated decrease in cell viability, and in a noticeable increase in replication time, only in lines with detectable Squalene epoxidase transcript |
746443 |
| 1.14.14.17 | medicine |
cholesterol lowering effect of green tea may be attributed to the enzyme inhibitory activities of its gallocatechins |
438210 |
| 1.14.14.17 | medicine |
expression of squalene epoxidase mRNA and protein in lung squamous cancerous tissues is significantly higher than in pericarcinoma tissues. The positive expression rate of squalene epoxidase mRNA is not associated with gender, age, smoking, or tumor size but closely correlated with poor differentiation, clinical stages, and lymphatic metastasis. The expression of mRNA is negatively associated with overall survival rate |
746530 |
| 1.14.14.17 | nutrition |
expression of myogenic marker genes (Myog, Myod, and Myh4) and adipogenic marker genes (Pparg, Cebpa, and Adipoq) is substantially downregulated in cells transfected with squalene epoxidase siRNA. mRNA expression levels of ROS scavengers, which affect meat quality by altering protein oxidation processes, are significantly downregulated by squalene epoxidase knockdown |
746469 |
| 1.14.14.17 | pharmacology |
squalene epoxidase is an attractive potential target for drugs used to inhibit the growth of pathogenic fungi or to lower cholesterol level in humans |
715725 |
| 1.14.14.17 | synthesis |
simultaneous overexpression of squalene epoxidase and 3-hydroxy-3-methylglutaryl coenzyme A enhances individual ganoderic acid production. The overexpressing strain produces maximum ganoderic acid-T, ganoderic acid-S, ganoderic acid-Mk, and ganoderic acid-Me contents of 90.4, 35.9, 6.2, and 61.8 microg/100 mg dry weight, respectively |
745145 |
