EC Number   |
Application |
Reference |
|---|
    1.14.14.14 | medicine |
allelic variants of CYP19A1 when present with a variant form of cytochrome P450 oxidoreductase POR may show different activities, and combined effects of natural variations in both the enzymes should be considered when genetic data are available |
765283 |
| 1.14.14.14 | medicine |
comparison of cerebrocortical microvascular responses to the endothelium-dependent vasodilator ACh between male and female wild-type and aromatase knockout (ArKO) mice. Wild-type female mice have significantly greater responses to ACh compared with wild-type males, which is associated with higher aromatase expression in female compared with male cerebral vessels |
743990 |
| 1.14.14.14 | medicine |
in an animal model of familial Amyotrophic lateral sclerosis, i.e. copper-zinc superoxide dismutase-1-G93A transgenic mice, the motor neurons in the spinal anterior horn express aromatase under normal and nearly normal (pre-symptomatic stage) conditions. After disease onset, astrocytes begin to express aromatase. The total level of aromatase expression decreases with disease progression |
744615 |
| 1.14.14.14 | medicine |
in the trophoblast choriocarcinoma cell line, JEG-3, the expression of let-7g microRNA is downregulated, but upregulated in primary term trophoblast. Aromatase is upregulated in JEG-3 cells but downregulated in primary trophoblast. Let-7g antagomirs and mimics increase and decrease aromatase expression, respectively, and Let-7g directly targets the 3'-untranslated region of CYP19A1 mRNAlet-7g antagomirs and mimics robustly increase and decrease production of estradiol, respectively |
765130 |
| 1.14.14.14 | medicine |
increased adipose tissue aromatase activity reduces adipose tissue inflammation and improves insulin sensitivity in male mice |
743988 |
| 1.14.14.14 | medicine |
phenolic endocrine-disrupting compounds DDT, methoxychlor, benzophenone-2, bisphenol A, bisphenol S, 4-phenylphenol and n-butylparaben upregulate aromatase mRNA expression, increase aromatase activity, significantly increase the aromatase-induced biosynthesis of 17beta-estradiol, and increase ERalpha positive breast cell proliferation |
765383 |
| 1.14.14.14 | medicine |
tumor-associated stroma tissues display high aromatase activities. High progesterone receptor intensity levels decrease this activity level. Tumor tissue specific aromatase activity levels of postmenopausal patients' tend to be lower compared to healthy premenopausal subjects'. Low aromatase activity in tumor tissues is associated with low grade and late stage cancers |
764643 |
