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EC Number Application Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 1.14.11.30analysis specific protocols for the knockdown and inhibition of the HIF prolyl hydroxylases 1-3 and the asparagine hydroxylase factor-inhibiting HIF using RNA interference and hydroxylase inhibitors, respectively 765338
Display the word mapDisplay the reaction diagram Show all sequences 1.14.11.30drug development the unique function of FIH makes it a prime target for selective inhibition leading to regulatory control of diseases such as cancer and stroke 725647
Display the word mapDisplay the reaction diagram Show all sequences 1.14.11.30medicine the high constitutive activities of the proteins with both Pro and Asn substitutions confirm that the relevant prolyl and asparaginyl hydroxylases are attractive targets for therapeutic regulation of hypoxia-inducible factor-1alpha and hypoxia-inducible factor-2alpha 701220
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