EC Number   |
Application |
Reference |
|---|
   1.13.11.12 | biotechnology |
the tomloxD gene encoding the enzyme has potential applications in engineering cropping plants that are resistant to biotic and/or abiotic stress factors |
726182 |
| 1.13.11.12 | food industry |
addition of LOX1 and LOX2 altered the elasticity as well as viscosity of dough prepared from bleached wheat flour, LOX improves the dough rheology |
-, 741646 |
| 1.13.11.12 | food industry |
lipoxygenase is widely used in food industry to improve aroma, rheological, or baking properties of foods |
-, 724085 |
| 1.13.11.12 | medicine |
15 lipoxygenase 1 is abundant in asthmatic human airway epithelial cells and binds phosphatidylethanolamine-binding protein 1 (PEBP1), leading to generation of hydroperoxy-phospholipids, which drive ferroptotic cell death. 15LO1, PEBP1, and glutathione peroxidase 4 GPX4 activity drives abnormal asthmatic redox biology, to enhance type 2 inflammatory responses. In vitro, type 2 inflammatory cytokine IL-13 induces 15LO1 generation of hydroperoxy-phospholipids, which lowers intracellular GSH and increased extracellular GSSG levels. Lowering GSH further by inhibiting cystine transporter SLC7A11 enhances type 2 inflammatory protein expression and ferroptosis. Ex vivo, redox imbalances correspond to 15LO1 and SLC7A11 expression, type 2 inflammatory biomarkers, and worsen clinical outcomes |
765145 |
| 1.13.11.12 | medicine |
15-LO-1 expression in colorectal carcinoma may contribute to the inhibition of metastatic capacity in vitro and can be exploited for therapeutic purposes |
703036 |
| 1.13.11.12 | medicine |
induction of 15-LOX-1-mediated down-regulation of a PPAR-gamma and COX-2 pathway by honokiol is a therapeutic strategy for gastric cancer |
711631 |
| 1.13.11.12 | medicine |
the LOX/4-nitroso-N,N-dimethylaniline method is able to highlight high antioxidant activity values in durum wheat grains, as well as synergistic interactions among antioxidants from different extracts, and so provide a more comprehensive and integrated determination of antioxidant activity, which is essential for a total antioxidant activity assessment and may provide a more realistic quantification of food antioxidant effectiveness in preventing diseases |
704118 |
| 1.13.11.12 | medicine |
when treating type 2 diabetic wild-type mice and transgenic mice ubiquitously overexpressing 15-LOX-1 with menhaden (fish) oil, there is a trend for the severity of diabetic peripheral neuropathy-related deficits to be less in the diabetic transgenic mice compared to the diabetic wild-type mice. Treating diabetic wild-type and transgenic mice with menhaden oil improves the diabetic peripheral neuropathy-related endpoints with a trend for greater improvement or protection by menhaden oil observed in the diabetic transgenic mice |
765147 |
| 1.13.11.12 | more |
the enzyme can be used for decolorization purposes in pulp, textile, and wastewater treatment industries |
-, 765704 |
| 1.13.11.12 | more |
the manipulating of the expression of the LOX gene may provide a basis for advancing both the fundamental and applied biology of rice |
706252 |
