EC Number   |
Application |
Reference  |
|---|
   3.4.21.108 | medicine |
way to limit renal injury by specifically inhibiting its proteolytic activity |
-, 667167 |
| 3.4.21.108 | medicine |
myocardial ischemia/reperfusion significantly increases cytosolic Omi/HtrA2 content and markedly increases apoptosis, ucf-101 can inhibit apoptosis |
668267 |
| 3.4.21.108 | medicine |
transfecting cells with siRNA molecules against Omi effectively eliminate Omi/HtrA2 protein expression |
668267 |
| 3.4.21.108 | medicine |
heterozygous G399S mutation in Parkinson's disease patients, which is absent in healthy controls, a A141S polymorphism is associated with Parkinson's disease, both mutations result in defective activation of Omi/HtrA2 and mitochondrial dysfunction associated with altered mitochondrial morphology |
668876 |
| 3.4.21.108 | medicine |
involvement of HtrA2 in the etiology of Alzheimer's disease |
670224 |
| 3.4.21.108 | medicine |
HtrA2 knockout mice display features characteristic of a Parkinson syndrome, deletion of HtrA2 results in increased susceptibility to cell death stimuli, Smac/DIABOLO can compensate for the removal of HtrA2 in terms of neutralizing inhibitor of apoptosis proteins |
670241 |
| 3.4.21.108 | medicine |
amyloid beta, a pivotal factor implicated in the pathogenesis of Alzheimer´s disease interacts with HtrA2/Omi |
670400 |
| 3.4.21.108 | more |
the bacterial protein quality control factor DegP is allosterically regulated by model peptides mimicking cellular stress signals. Strategy for the development of antimicrobials |
683076 |
| 3.4.21.108 | more |
simple and rapid strategy for molecular cloning using a gel-free and antibiotic selection method, which allows for the complete elimination of DNA extraction by gel electrophoresis, and thus has several advantages over gel-based cloning methods, including a cloning efficiency that is approximately 10times higher due to the prevention of ethidium bromide ultraviolet-induced DNA damage and contamination with ligase inhibitors, the amount of plasmid DNA required is approximately five times less, and cloning time is several hours less |
685760 |
| 3.4.21.108 | medicine |
link between HtrA2/Omi and Parkinsons disease or Alzheimers disease |
686002 |
